Most of the weird-looking keyboards have the same QWERTY layout. If you can touch type, they don’t take long to get used to. I personally don’t get the people that change their keyboards to DVORAK or COLEMAK (Not sure why I shout those names, just the way I tend to write them). More power to them, but I think if I changed the layouts like that it would take me months to get back up to speed.
I tried out Colemak for a couple months about 10-15 years ago. I just could not get my stupid head to wrap around it. Knock on wood I haven’t had any pain issues, but I’ve been using an ergodox since I got one of those group buy ones that I had to solder together. I actually bought a stenography keyboard recently. I’m trying to spend a little bit each day learning it, but I expect that to take years.